Abstract

OOCYTES QUALITY AFTER ORAL ADMINISTRATION OF OVA MAX® IN FEMALE MICE: EXPERIMENTAL MODEL FOR MAMMALS.

Prof. Dr. Saad S Al-Dujaily* PhD and Dr. Ali M. Naema M. Sc

Abstract

Background: Ova Max® is a new nutrient supplements containing vitamins, minerals, enzymes, amino acids and hormones. All may sustain the oocyte quality and ovarian function, at the same time protect oocyte from free radicals damage. Objective: The goal of the thesis is to examine the effect of Ova Max® on oocyte maturation. Materials and Methods: Forty mature female mice were involved in this study that conducted at the High Institute of Infertility Diagnosis and Assisted Reproductive Technologies through the period from September 2014 to April 2015. The animals were divided into three groups. The first group, the mice ages was (16) weeks old and The second group, the mice ages was (32) weeks old: independently the mice of each group were divided into three subgroups according to Ova Max® doses (0.2,0.4, 0.8 mg / kg ) , The third group was the control group divided into two main groups , Five mice (16 weeks old) and Five (32 weeks old]. Similar sub grouping and parameters assessment of treated mice was done for the control group. All the female mice were stimulated with super ovulation induction program. Ova Max® was treated by oral administration for 30 day. Results: The results indicated that the treatment with Ova Max® showed a significance (p˂ 0.05) improvement in oocytes maturation status in treated group of dose 0.2 and 0.4 mg/kg OM in age (32) week compared with control group at the same age. Conclusions: It was concluded that the treatment by Ova Max® has a great improvement in oocyte maturation with low dose for aged mice. This data can be used for human and other mammals to sustain the fertilization capacity and normal embryonic development.

Keywords: Ova Max®, oocytes quality aged mice.