Abstract

FORMULATION OF SUSTAINED RELEASE METFORMIN HYDROCHLORIDE MATRIX TABLETS THROUGH OPTIMIZATION AND THEIR EVALUATION

Masheer Ahmed Khan*

Abstract

The object of the present study was to prepare and evaluate sustained release metformin hydrochloride matrix tablets. Metformin HCL, the only available biguanide, remains the first line drug therapy for patients with Type 2 diabetes mellitus acts by decreasing hepatic glucose output and peripheral insulin resistance. It has relatively short plasma half life, low absolute bioavailability. The need for the administration two to three times a day when larger doses are required can decrease patient compliance. This is improved by developing sustained release formulations of drug candidate. Sustained release matrix tablets were prepared using combination of hydrophilic polymer HPMC K15M and hydrophobic polymer ethyl cellulose as rate controlling factor. Optimization techniques using factorial design for two factors at three levels (32 ) was selected to optimize varied response variables viz. release rate exponent (n), k, amount of drug released in 12h (Rel12h) and mean dissolution time MDT. The optimum formulation was selected and the results obtained with the experimental values were compared with the predicted values. In conclusion, the results suggest that the developed sustained-release matrix tablets could provide quite regulated release of metformin hydrochloride over an extended period of time12 hrs leading to improve efficacy and better patient compliance.

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