Abstract

DNA SEQUENCING OF CAG REPEAT OF ANDROGEN RECEPTOR GENE OF PROSTATE CANCER PATIENTS IN THE SOUTH OF IRAQ

Dr. Manal Badi Salih Al-Tamemi*,
Raed Saddam Madhi Al-Saadi

Abstract

The present study was designed to investigate some epidemiological and DNA sequencing study, in a sample of Thi-Qar, Basarh, Missan provinces south of Iraq. The sample included (32) patients with (32) healthy men as a control The diagnosis was made by the consultant medical staff, which was based on a history inspection, and clinical examination. The epidemiological results were revealed that there were a significant differences in the distribution of prostate cancer, where Basrah province recorded the highest percentage (75%) of prostate cancer in comparison with Thi- Qar in percent ( 15.6% ) , and ( 9.3%) in Missan. Our results revealed the highest number of patients filled in age (60-69) years and age (≥ 70) years, and low numbers in age group(50-59) years represented by (43.75, 40.62, and 15.62%, respectively). DNA sequencing examined (32) patients with prostate cancer and (32) controls to determined the relationship between prostate cancer and CAG repeat of androgen receptor gene, where shorter repeat recorded high percentage compared with controls (37.5% vs 3.1%), while longer CAG repeat of patients recorded low percentage compared with controls (62.5% vs 96.87%).

Keywords: Index Terms- prostate cancer, CAG repeat.