Abstract

CO-AMOXICLAV RESISTANCE BY SOME BACTERIA SPECIES ISOLATED FROM HOSPITALS IN KHARTOUM STATE, SUDAN

Ali H. Rabbad*, Alaa E. Elawni and Dr. Sameer Ghorashi

Abstract

The aim of this study is to assess the resistance of some species of bacteria against co-amoxiclav (amoxicillin+ calvulanic acid). The study was carried out on 66 samples (43 S. aureus 65.2%, 18 E.coli 27.3% and 5 proteusspp 7.6%), which have been collected and clinically isolated from different specimens (wound infection - UTI - blood - abscesses and others) from patients in four major hospitals in Khartoum state, Sudan (Zaitouna Hospital -Yastapshiroun Hospital - Al-amal Hospital and Soba Hospital). A susceptibility tests for three types of antibiotics (Co-amoxiclav, amoxicillin and methicillin) had been done using diffusion method. The results showed that 15.4% from the samples are sensitive to the co-amoxiclav, 1.9% intermediate and 82.7% were found to be resistant. It has been concluded that coamoxiclav resistance is increasing rapidly and a special care should be given from the authorities to this increase and for prescribing this antibiotic with the importance of involving the susceptibility test before prescription, so as to control the resistance acquired by the bacteria against this antibiotic.

Keywords: Co-amoxiclav, amoxicillin, methicillin, resistance.