Abstract

IN VITRO EVALUATION OF LOADED PACLITAXEL ON THE NIOSOME NANOPARTICLES AND ITS CYTOTOXIC EFFECTS ON THE CELL LINE OF OVARIAN CANCER A2780S

Mahdi Izadi, Meysam Ebrahimifar, Mohsen Chiani, Arezoo Beig Parikhani, Fatemeh Golak, Hamed ebrahimi, Azim Akbarzadeh, Hemen Moradi-Sardareh*,

Abstract

Today, cancer is one the most important challenges in modern medicine. Meanwhile, ovarian cancer is one of the most common causes of mortality among cancers. The initial response to the treatment and then becoming resistant to the paclitaxel is one of basal challenges of treatment of ovarian cancer. Recently, using nanotechnology including drug nanocarrier named niosome can decrease adverse effects and increase the efficiency of treatment. The aim of this research is using niosome nanoparticles containing paclitaxel and investigation of their lethal effect on ovarian cancer cell line. Niosome nanoparticle is prepared by injection ether method. The research found that by using of niosome nanoparticles can be provided a suitable formulation of paclitaxel drug. Therefore, the results show the efficiency of nanoniosome paclitaxel is more than free drug. This decreases used dose and therefore the damage of other tissues.

Keywords: Nanoniosome, Paclitaxel, ovarian cancer, Iran.