Abstract

SYNTHESIS AND SIGNIFICATION OF 1,4-DIHYDROPYRIDINES ANALOGS IN DIFFERENT PHARMACEUTICAL DRUG.

Ajit. K. Nangare*, Sudarshan B. Kakad, Amit. N. Chavan and Sandesh S. Bole

Abstract

In the recent past year, The 1,4-dihydropyridines derivatives have been covering a large area of studding because of their synthetic possibility, different chemical behavior, there biological activities and different applications in the pharmaceutical drug. The 1,4-benzothiazine forms an important class of heterocyclic system, it include the N and Smolecules in the ring. The novel 1,4-benzothiazine derivatives occupancy several biological activities such as anti-inflammatory, antirheumatic, antimicrobial, antioxidant, anti-hypertensive, anti-HIV, cardiovascular , ATP-sensitive potassium channel opener, ant malarial, cytotoxic, immunomodulation, neuroprotective and aldose reeducates inhibitor etc.

Keywords: antitumor, anti-inflammatory, 1, 4-dihydropyridines, anticonvulsant, synthesized.