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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

EVALUATION OF ANTIHYPERTENSIVE ACTIVITY ON AQUEOUS LEAVES EXTRACT OF MURRAYA EXOTICA LINN. IN RENAL ARTERY OCCLUDED HYPERTENSIVE RATS

Kanakam Vijayabhaskar*, Kalakota Chaitanya Prasad, Gajavelli Bharath Kumar

Abstract

Aqueous extract of Murraya exotica Linn. (Family: Rutaceae) was evaluated for its antihypertensive activity in renal artery occluded hypertensive rats. Male Wistar rats (180-200g) were pretreated with aqueous extract of Murraya exotica for 6 weeks. Hypertension was induced in animals by clamping the renal artery with renal bulldog clamp for 4 h. Ischemia of the kidneys causes elevation of blood pressure by activation of the renin-angiotensin system. Elevated blood pressure of the animals was significantly (p

Keywords: Murraya exotica, antihypertensive activity, rennin-angiotensin system.

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