Abstract

FETUIN-A IN PATIENTS WITH KIDNEY DISEASE

Feryal H. Rada*

Abstract

Urinary exosomes containing apical membrane and intracellular fluid are normally secreted into the urine from all nephron segments and may carry protein (like Fetuin-A) a marker of renal dysfunction and structural injury. This study was designed to assess the use of urinary fetuin -A biomarker in patients with chronic kidney disease (CKD). A study was done on 40 patients (25 males and 15 females), aged (62 years ±8) with chronic kidney disease and 30 healthy subjects (12 males and 18 females), aged (60 years± 6). Renal function tests, lipid profile and urinary levels of fetuin-A and α1 –microglobulin were measured and studied. The statistical results of urinary fetuin –A and α1 –microglobulin levels showed high significant increases (P˂ 0.001) in patients with chronic kidney disease versus control subjects (1.32 ng/gcr. ±0.88 vs. 0.34 ng/gcr. ±0.28), (15.03μg/gcr.±18.05 vs. 3.5 μg/gcr.±2.7) respectively. Moreover, the urinary fetuin–A levels increase 3.88 folded in chronic kidney disease patients compared with control healthy subjects. Therefore urinary Fetuin-A may be used to predict the progression of renal injury.

Keywords: Chronic kidney disease, fetuin-A, ?1 -Microglobulin.