Abstract

MAGNETIC MICROSPHERES AS NOVEL EXPANSION IN MULTIPARTICULATE DRUG DELIVERY SYSTEM

Shaikh Siraj*, G. J. Khan, Patel Afroza, Patel Huzaifa, Wedachchhiya Sufiyan, Shaoor
Ahmad, Sanjay Padvi

Abstract

Main objective of targeted drug delivery is selective and effective availability of active pharmaceutical ingredients into the target site at therapeutic concentrations. Various approaches are used for drug targeting using single as well as multiparticulate. Recentally in multiparticulate Magnetic microspheres is novel approach used for drug targeting. Microspheres are better choice of drug delivery system than many other types because it is having the advantage of detection of bimolecular interactions and better patient compliance. Magnetically targeted drug delivery by microspheres is an efficient method of delivering drugs to localized disease sites. Magnetic microspheres hold great promises for reaching the goal of controlled and site specific drug delivery. Magnetic microspheres as an alternative to traditional radiation method which uses highly penetrating radiations that is absorbed throughout the body. Magnetic drug delivery is a novel approach to delivery drug using engineered ’smart’ micro carriers which appears to overcome a number of limitations facing current methods of delivering medicines. The drug and a suitable ferrofluid are formulated into a pharmaceutically stable formulation which is usually injected through the artery that supplies the target organ or tumor in the presence of an external magnetic field. This review focus on various aspects of the magnetic microspheres like mechanism, benefits, fabrication &various applications of magnetic microspheres.

Keywords: Drug delivery, Magnetic microspheres, Targeted drug delivery, Magnet, Dosage form.