Abstract

HEPATOPROTECTIVE EFFECT OF POLYHERBAL FORMULATION “MENTAT” AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN RATS

Chetan Rastogi, Syed Anees Ahmed, Dr. Talha Jawaid*, Rajan Awasthi, Kalpana, Mehnaz Kamal

Abstract

Hepatotoxicity implies chemical-driven liver damage. Certainmedicinal agents, when taken in overdoses and sometimes even whenintroduced within therapeutic ranges, may injure the organ.The currentstudy was done to investigate the hepatoprotective effect of Polyherbalformulation Mentat against CCl4 induced hepatotoxicity in rats.Sprague-Dawley rats (male) weighing 200-250 g was used.Hepatotoxicity was induced by administration of 50% CCl4 in olive oilintraperitoneally every 72 hr for 10 days. Silymarin was used asstandard in dose of (0.5 ml/100 g b.w.) and the test drug Mentat wasused in dose of (2 ml/kg) was orally administered before or after CCl4treatment in various groups. Serum glutamic oxaloacetic transaminase (SGOT), Serumglutamic pyruvic transaminase (SGPT), Alkaline phosphatase (ALP), Total bilirubin (TB)parameters were estimated. Serum SGOT, SGPT, ALP and TB activities significantlydecreased (p < 0.05) as compared to CCl4 treated group. The present study demonstrated thatMentat possesses hepatoprotective effects against CCl4 induced hepatotoxicity and that theeffects are both preventive and curative.

Keywords: Carbon tetrachloride, SGOT, SGPT, ALP, TB, Mentat, Silymarin.