Abstract

DESIGN AND RELEASE STUDY OF DENTAL IMPLANTS CONTAINING METRONIDAZOLE API FOR PERIODONTAL DISEASE

Hariom Sharma* and Kaushal K. Chandrul

Abstract

A controlled drug delivery dental implant designed for the treatment of periodontal disease with the aim of site‐specific delivery of metronidazole, which has excellent activity against anaerobic microorganisms. The calibration curve for metronidazole was developed in pH 6.6 phosphate buffer at 287.6 nm in the range of 2 to 14 μg/ml. Metronidazole Dental implants were prepared by solvent casting technique using polymer ethyl cellulose acetate in two different concentrations with three Plasticizers in Acetone alone and in combination as chloroform: Acetone (1:1) solvent with Dibutylphthalate, PEG- 600 and in combination as plasticizers. No interaction between Metronidazole and polymers are found and is shown by FT‐IR and UV spectroscopic methods. The dental implants were evaluated for their thickness uniformity, folding endurance, weight uniformity, content uniformity, tensile strength, surface pH and vitro release pattern. In vitro release from implants was fit to different equations and by kinetic models to reveal release kinetics. Kinetic models were studied for zero order, first‐order equations and Hixson‐Crowell and Higuchi models. Controlled release of drug is found in all batches of dental implants. A short‐term stability study shows that drug content decreased in various films and was ranging from 0.8% to 3.02%.

Keywords: Periodontal disease; Dental implant; Metronidazole; Cellulose acetate; Controlled release; In-vitro release.