Abstract

IN VIVO ANTICANCER SCREENING OF ‘PORTULACA QUADRIFIDA LINN’ON COLON CANCER

Shaik Mohd Khasim* and Dr. E.P Kumar

Abstract

Among all the carcinogenic diseases colon cancer is most commonly occurring cancer in developing countries. Many researchers had concluded that herbal source can be useful for the successful management of colon cancer. In this study we recruited a therapy with less side affects when compare to synthetic drugs using aqueous extract of Portulaca quadrifida a vegetative plant found in tropical parts of India by In vivo anticancer screening engrafted in male Sprague Dawley rats. In the view of characteristics of our work; For In vivo study, colon cancer was induced with the chemical carcinogen (DMH) and after treatment with the aqueous extract of Portulaca quadrifida for 16 weeks, the various In vivo parameters were evaluated. The In vivo antioxidant levels, carbohydrate metabolizing enzymes were increased in compound (200 and 400 mg/kg, p.o.) treated groups compared to control animals in a dose dependent manner. In vivo data thus obtained suggested that aqueous extract of Portulaca quadrifida is having good activity against the various biochemical parameters as compared with negative control group. The activity may be due to saponins content. Histopathalogical studies with aqueous extract of Portulaca quadrifida at 400mg/kg body weight showed no obvious abnormality in structure of colonic mucosa, which was very well comparable with biochemical, hematological, antioxidants and tumor markers estimation. With the above said findings we concluded that the plant Portulaca quadrifida posse’s anticolorectal cancer activity, before its clinical usage, through toxicological profile has to be determined to confirm the safety of the drug.

Keywords: Portulaca quadrifida, Colon cancer, In vivo.