Abstract

ANTHELMINTIC ACTIVITY OF ETHANOL AND ETHYL ACETATE EXTRACTS OF TECOMARIA CAPENSIS. (FAMILY: BIGNONIACEAE)

E. Tamil Jothi, Ch. Harini* and G. Nagarjuna Reddy

Abstract

Ethanol and ethyl acetate extract of Tecomeria capensis (Bignoniaceae) was investigated for the activity against Indian earthworms Pheretima posthuma. Various concentrations of extract (25-100mg/ml) were tested, which involved determination of time of paralysis and time of death of the worms. Ethanol and ethyl acetate extract at the tested dose were produced significant activity. The maximum activity of ethanol and ethyl acetate extract of Tecomeria capensis was 8.55 and 8.50 minutes respectively as time of paralysis, 32.25 and 32.10 minutes respectively as time of death at the dose of 100 mg/ml. Albendazole (20 mg/ml) which is included as standard reference showed 31.86 minutes as time of paralysis, 42.5 minutes as time of death. 0.5% w/v of carboxymethyl cellulose used as control there is no paralysis and death of earth worms. The present study indicates ethanol and ethyl acetate extract of Tecomeria capensis acts as potential anthelmintic agent.

Keywords: Albendazole, Anthelmintic activity, Pheretima posthuma, Paralysis time, Death time, Tecomeria capensis.