Abstract

STUDY OF CHANGES IN SERUM GLYCOPROTEIN LEVELS IN OSTEOPOROSIS PATIENTS

Nilesh S. Bhavsar* and Dr. Ranjit Kaur

Abstract

Glycoproteins can be simply defined as proteins which have carbohydrates covalently attached to their peptide portion. Glycoproteins are proteins which contain monosaccharides like hexose, hexosamine, fucose and sialic acid. This study was carried out on total 110 subjects, comprising the normal subjects and the patientsof osteoporosis. Normal subjects and all the patients of osteoporosis were diagnosed and selected by orthopedic surgeon from S.S.G. Hospital, Baroda and then taken for study. Blood (5 ml) was collected in plain bulbs and serum is separated by centrifugation. Serum is kept under refrigeration at 4ºc until use. There is an increase in Serum glycoproteins level in Patients of Osteoporosis (With Postmenopausal Women) and in Patients of Osteoporosis (Other than Postmenopausal Women). Also there is decrease in Serum glycoproteins levels observed in Patients Undergoing Treatment. But Treatment did not bring down the level of Serum glycoproteins to normal level. So it is suggested that the increase in Protein Bound Hexose (PBH), Protein Bound Hexosamine (PBHA), Protein Bound Fucose (PBF), Protein Bound Sialic Acid (PBSA) and Protein Bound Carbohydrates (PBC) in Patients of Osteoporosis could be due to enhanced glycosylation of Protein in Osteoporosis. Also Osteoporosis usually causes no symptoms until a fracture occurs but it can cause back pain or loss of height.so evaluation of serum PBH, PBHA, PBF, PBSA and Carbohydrates (PBC) may be used as an alternative methods and markers for diagnosis of Osteoporosis.

Keywords: Glycoproteins, hexose, hexosamine, fucose, sialic acid. Osteoporosis.