Abstract

PHYTOCHEMICAL INVESTIGATION AND EVALUATION OF WOUND HEALING POTENTIAL OF CRUDE LEAVE EXTRACTS OF DALBERGIA SISSOO (ROXB.), IN WISTAR RATS

Sangram K. Panda*, Ram P. Padhy, Gayatri D. Rout Ray and Subhashree. Padhy

Abstract

The present study was an attempt to investigate the phytochemicals and wound healing potential in two different types of wound models in albino rats viz., incision and excision of various extracts of Dalbergia sissoo leave.The different crude extracts such as ethanol, ethyl acetate, n-butanol and petroleum ether are obtained by successive soxhlet extraction. The ethanolic extract showed significant increase in wound contraction and formation of scar in excision wound model. The extract showed significant increase in the breaking strength of resutured incision wound as compared to control group(p<0.05). The result of the present study indicate that ethanolic extract of D. sissoo has more significant wound healing property than the other three extracts in excision and incision wound model. The literature survey reveals that there are no reports on the wound healing activity of the leaf extracts of Dalbergia sissoo. This prompted the authors to undergo the present study.

Keywords: Dalbergia sissoo; Excision and incision wound model.