Abstract

OSTEOPOROSIS AND ASSOCIATED FACTORS AMONG PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN JIMMA UNIVERSITY SPECIALIZED HOSPITAL, JIMMA, ETHIOPIA

Tariku Anjamo, Elsah Tegene and Samuel Tadesse*

Abstract

Osteoporosis is one of the systemic features of chronic obstructive pulmonary disease and its prevalence is assumed to be two-to fivefolds greater than in sex and age matched healthy subjects. This study was designed to assess the prevalence of osteoporosis and associated factors among patients with chronic obstructive pulmonary disease attending chest clinic of the Jimma University Specialized Hospital. In this cross-sectional study, data were collected using dual-energy X-ray absorptiometry, bone mineral density scan of 2nd to 4th lumbar spine for three repetitive measurements and from the patient‟s medical chart (doses and frequency of corticosteroid therapy) and other potential factors via structured questionnaires. The collected data were analyzed using SPSS version 21. Binary logistic regression was used to control the potential confounders and the strength of the association was expressed in an adjusted odds ratio with 95% confidence interval. Finally, an association with p-value < 0.05 was considered as statistically significant. Among 80-patients with chronic obstructive pulmonary disease evaluated; the prevalence of osteoporosis was found to be 33(41.3%). Cigarette smoking [AOR= 4.949; 95% CI: 1.323, 18.508] and corticosteroid therapy [AOR= 4.768; 95% CI: 1.258, 18.065] were the two variables which were found to be significantly associated with osteoporosis (p- value < 0.05). This study comes with high prevalence of osteoporosis among patients with chronic obstructive pulmonary disease in Jimma University Specialized Hospital. Factors such as smoking cigarette and doses of corticosteroid therapy were found to be significantly associated with osteoporosis.

Keywords: Prevalence, DEXA, BMD, T- score, osteoporosis, COPD.