Abstract

MAGNETIC PILLS AN ATTRACTIVE DELIVERY SYSTEM: A REVIEW

Sanjay Sambhaji Dudhamal*, Vijayananda K. Khadkutkar, Manjusha A. Bhange

Abstract

“Magnetic drug delivery systems have been emerged as a prominent technique for site-specific targeting of various pharmacological agents throughout the last few decades”. With the support of a magnetic field, it avoids reticule endothelial system and directs the drugs to reach the target precisely. Magnetic carriers like nanoparticles, microspheres, liposomes and emulsion have been found advantageous of the fact that they reduces the free drug concentration in the blood and to minimize the adverse effects provoked by these drugs. Recent decades have shown a vast range of applications in the field of magnetic nanotechnology as it has expanded its scope to oncological, cardiovascular and neurological disorders. They have been under keen investigation in different fields as next generation drug carriers due to their physical properties. Magnetic nanoparticles have displayed a great potential in drug loading proficiency due to their magnetic core intrinsic capabilities and physico-chemical properties due to the coating efficiency. Numerous therapeutics demonstrates optimal absorption or activity at specific sites in the gastrointestinal (GI) tract. Effective pill retention within a desired region of the GI remains an elusive goal. We report a safe, effective method for localizing magnetic pills. To ensure safety and efficacy, we monitor and regulate attractive forces between a magnetic pill and an external magnet, while visualizing internal dose motion in real time using biplanar video fluoroscopy.

Keywords: Magnetic pills system, structurally principle, classified character, challenges.