Abstract

DESIGN AND EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEM OF ANTI DIABETIC DRUG

Harshitha M. S., Senthil Kumar Krishnan*, Arul Selvam T., Mahesh K. G., Detroja Purusharthm

Abstract

The aim of the present investigation was to prepare Glipizide Transdermal patches of matrix type and membrane controlled type using the Eudragit RL 100 and Eudragit RS 100 in different ratios by the mercury substrate method. The systems were evaluated for various in vitroand in vivo parameters (Thickness, Folding endurance, Moisture content, Moisture uptake, Water Vapor Transmission rate, Drug content, Drug permeation, Drug–polymer interactions and Scanning electron morphology and Skin irritation studies, hypoglycemic activity). Drug content of the patches was found to be more than 97%. In vitro permeation studies were performed by using Franz diffusion cells. Variations in drug permeation profile were observed among various formulations. The SEM of the patch showed the formation of pores on the surface after in vitro permeation studies. The drug–polymer interaction results suggested no interaction between drug and polymers was observed. From all the formulations, formulation D 3 was selected as the best formulation and formulation was stable for period of study (90 days).

Keywords: Transdermal drug delivery; Matrix patch; Membrane controlled Patch; Glipizide; Eudragit; In vitro and In vivo skin permeation studies.