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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

BISMUTH (III) BROMIDE AS AN EFFICIENT CATALYST FOR THE MULTI-COMPONENT SYNTHESIS OF DIHYDRO-2-OXYPYRROLES

Manjula Krishnappa* and Shekar H.S

Abstract

A simple and efficient protocol has been developed for the synthesis of dihydro-2-oxypyrroles via multi-component reaction of amines, dialkyl acetylene dicarboxylates and formaldehyde amines in the presence of Bismuth (III) bromide as a promoter stirred at 75oC for 3 hrs has been investigated. The significant advantages of this protocol are mild reaction conditions, low toxicity bismuth compound, inexpensive material, short reaction times, good yields, simple work-up.

Keywords: Bismuth (III) bromide (BiBr3), dihydro-2-oxypyrroles, dialkyl acetylene dicarboxylates, formaldehyde and amines.

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