Abstract

COMPARATIVE EVALUATION OF CA15-3 EFFICIENCY AS A DIFFERENTIAL BIOMARKER TO THE EARLY DIAGNOSIS OF BOTH BREAST AND OVARIAN CANCER IN EGYPTIAN FEMALES

Samia A Ahmed, Hanan F. Aly* and Omar S. Omar

Abstract

To examine the possible involvement of human CA15-3 in in early diagnosis of breast and ovarian cancer among Egyptian females, serum activity ofthis biomarker was demonstrated by the method of Enzyme Linked Immunosorbant Assay. Five groups of subjects (20 for each), were examined in this study for breast cancer. Healthy control ,breast cancer patients with grad I , II and two treated groups with grade I and II . In addition, five groups of ovarian cancer women (25 each), were divided similarly as in breast cancer groups. The present results declare that, drastic significant increase in CA15-3 level (p ≤ 0.05), in breast than ovarian cancer patients, with age and grade dependent (grade II in both tumor types showed significant increase in CA15-3 level than grade I), as compared to healthy control group (p ≤ 0.05) . In addition, treatment of breast and ovarian cancer exhibited significant increase in CA15-3 levels with age and grade dependent. Moreover, the manipulated data showed, positive Pearson’s correlations between CA15-3 biomarker , age , grade , breast , ovarian cancer and the corresponding treatments .These findings imply that, CA15.3 is expressed in many malignant disease including breast and ovarian cancer. Although, CA15-3 has high specificity low sensitivityand it more expressed in breast than ovarian cancer and it can be used as a prognostic marker in breast cancer as well as after treatment more than in preoperative surgery of ovarian cancer and treated patients.

Keywords: Breast cancer, Ovarian cancer, Tumor, CA15-3, biomarkers.