Abstract

ANTISPASMODIC EFFECT OF N-BUTANOL EXTRACT OF SOLENOSTEMMA ARGEL HYNE LEAVES ON ISOLATED RAT ILEUM.

Amna Elhassan Hamad Mohammad*, Bashir Mohamed Ahmed, Sumia Bashir Bokhari

Abstract

The present study was aimed to provide the pharmacological basis for medicinal use of Solenostemma argel Hyne leaves, as an antispasmodic agent using in-vitro pharmacological assay. Antispasmodic activity of n-butanol extract of Solenostemma argel Hyne leaves was evaluated for its antispasmodic effects against acetylcholine- induced contractile activity on isolated rat ileum preparations. The extract inhibited the contractile response elicited by acetylcholine on rat ileum significantly and in a concentration-dependent manner. The present study results revealed that, n-butanol extract of Solenostemma. argel Hyne leaves possesses a promising antispasmodic action confirming and justifying its use in folk medicine for the treatment of gastrointestinal disorders.

Keywords: Spasmolytic effect; Solenostemma argel Hyne; Rat Ileum.