Abstract

ANTIHYPERLIPIDEMIC ACTIVITY OF ARGYREIA NERVOSA ROOT EXTRACT IN TRITON X-100 INDUCED HYPERLIPIDEMIC RATS

V. Srilatha Goud*, S. Ravindra Babu and N. Srinivas

Abstract

The present study was aimed to investigate the anti-hyperlipidemic effects ethanolic extract of Argyreia nervosa root (EANR)in Triton X- 100 induced hyperlipidemia in rats. The lipid profile was taken as the major marker of Hyperlipidemia and accordingly the changes in serum total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL-C), and high density lipoprotein (HDL-C) were measured (using enzymatic kits) after treatment with EANR and standard (atorvastatin). The effect of extracts on hepatic enzymes, Serum glutamic oxaloacetic transaminase (SGOT), Serum glutamic-pyruvic transaminase (SGPT) and alkaline phosphatase (ALP) were determined as a measure of hepatotoxicity. The oral administration of EANR (250 and 500 mg/kg body weight) showed significant reduction of TC, TG, LDL, VLDL and an increase in HDL levels were observed in a dose dependent manner. When compared to Triton X-100 group, reduction in SGOT, SGPT and ALP levels were also observed which indicates the hepatoprotective potential of the extract. Based on the results obtained, it can be concluded that EANR has significant antihyperlipidemic properties and can be used in the treatment of vascular disorders including atherosclerosis. Preliminary analysis revealed the presence of phytoconstituents such as saponins, glycosides and tannins.

Keywords: Antihyperlipidemic, Atorvastatin, Triton X-100, Argyreia nervosa root, TG.