Abstract

EVALUATION OF ANTIULCER ACTIVITY OF FRESH JUICE OF THE LEAVES OF PEDALIUM MUREX

Vaya Rajkumar*, Modi Harshil and Vaya Rajesh

Abstract

Peptic ulcer is manifested largely due to an alteration in lifestyle and diet. Gastric ulcer is one of the most serious diseases in the world. Although there are many drugs used for the treatment of gastric ulcer, most of these produce several adverse reactions.The objective of this study was to investigated Pedalium murex (Pedaliaceae) for the antiulcer activity. The study has been done to evaluate the antiulcer effect of fresh juice of the leaves of Pedalium murex on ethanol induced time and dose dependent ulcers. The results obtained from the present study have been shown that fresh juice of the leaves of Pedalium murex possesses antiulcer effect on ethanol induced ulcers. In ethanol and stress induced model, there is decrease in ulcer index, total acidity, total volume of gastric secretion, total protein and increase in glutathione content and pH of gastric secretion when compared with control. In the present study Famotidine has been used as a standard. Therefore the ethanolic extract of leaves of Pedalium murex could be regarded as a favorable antiulcerogen.

Keywords: Pedalium murex; Antiulcer activity; Peptic ulcer.