Abstract

DESIGN AND CHARACTERIZATION OF TRAMADOL HYDROCHLORIDE SOFT LOLLIPOPS

Nethravani G.*, Jagadeesh P. and Dasthagiri S.

Abstract

The oral route is the most preferred route of administration of drugsbecause of low cost of therapy, ease of administration, patientcompliance and flexibility in formulation. The illness are associatedwith fever, head ache and body aches so to cure the above/relief fromthe above, there was need to administer the drugs to the individuals butin case of pediatric patients it was difficult to administer the dosageforms like tablets, capsules, etc. In the present investigation an attempthas been made to prepare and evaluate the sugar based medicatedtramadol hydrochloride soft lollipops for pediatrics to overcome theadministration. They were prepared by heating and congealing methodon laboraty scale with malt syrup as base. All the formulations weresubjected to various physico-chemical parameters such as hardness,friability, content uniformity, weight variation, thickness, drug content and in vitrodissolution studies. Drug-excipients compability stuidies were conducted by FT-IRspectroscopy and results revealed that no interactions were found between drug andexcipients. The results of in vitro drug release studies showed that formulations F30, F33 andF36releases the drug 94.4, 97.7 and 93.8 percentage at the end of 30 mins. The soft lollipopscan provide an attractive alternative formulation in the treatment of pain in pediatric patients.

Keywords: Tramadol Hydrochloride lollipops, HPMC: Hydroxy Propyl Methyl Cellulose, Na CMC: Sodium Carboxyl Methyl Cellulose, MC(Methyl Cellulose).