Abstract

CARDIOPROTECTIVE EFFECT OF PERGULARIA DAEMIA

Sridevi G., Sembulingam K.*, Prema Sembulingam, Mohammad Ibrahim

Abstract

The bioactive components and antioxidants in Pergularia Daemia (PD) function as an effective anti-inflammatory agent as reported in our earlier studies. In the present study, the cardio-protective effect of ethanol extract of PD against acute and chronic noise stress was assessed by evaluating the level of stress index viz., plasma corticosterone and the cardiac enzymes viz., serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT) and lactate dehydrogenase (LDH) in serum which were the indicators of the extent of damage done by the noise stress. The levels of antioxidants in myocardium viz. superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), malonaldialdehyde (MDA) (lipid peroxidation) and vitamin C were also estimated as supporting evidence. It was further confirmed by histological sections of cardiac tissues in albino rats. The results revealed that acute noise stress (45 minutes once) significantly increased plasma corticosterone but did not alter the levels of cardiac enzyme and antioxidant levels. Chronic noise stress (21 days) significantly decreased plasma corticosterone (p < 0.05) and antioxidant levels and increased SGOT, SGPT, LDH and MDA levels revealing the damage done to the cardiac tissue. Histological examination of the cardiac tissue confirmed the damage done by chronic noise exposure through the multiple hemorrhages with infiltration of inflammatory cells. PD extract (200 mg/kg) effectively prevented all these changes in acute and chronic noise stress proving the antistressor and cardio-protective effects of PD.

Keywords: Pergularia Daemia, Cardio-protective effect, Noise stress, Cardiac injury markers, Antioxidants