Abstract

EFFECT OF LONG ACTING OXYTETRACYCLINE ON IMMUNE RESPONSE BASED ON HAEMAGGLUTINATION TITRE IN RATS

Ravikumar C.*, Jagadeesh S. Sanganal, Shridhar N. B., Narayanaswamy H. D., Sunilchandra U. and Shivashankar B. P.

Abstract

The immune system expresses an adaptive response in all the vertebrates against invading microorganisms. The role of immune system is to sustain host defense mechanisms and maintain homeostasis. Long acting oxytetracycline administered at 20and 40 mg/kg body weight mg/kg body weight through intramuscular route in wistar albino rats. Sheep RBC used as antigen.The immunological parameter of haemagglutination titre was studied in this study. For Haemagglutination titre, there was no significant (P>0.05) difference in the antibody titre in the antigen plus long acting oxytetracycline low dose and high dose group when compared to antigen and antigen plus pyrrolidone control grou. Thus the study concluded that the long acting acting oxytetracycline did not affect the humoral mediated immnune response in rats.

Keywords: Long acting Oxytetracycline, Haemaggluntination Titre, Immune response.