Abstract

EFFECT OF LONG ACTING OXYTETRACYCLINE ON IMMUNE RESPONSE BASED ON PHAGOCYTIC INDEX IN RATS

Ravikumar C.*, Jagadeesh S. Sanganal, Shridhar N. B., Narayanaswamy H. D., Sunilchandra U. and Shivashankar B. P.

Abstract

The immune system expresses an adaptive response in all the vertebrates against invading microorganisms. The role of immune system is to sustain host defense mechanisms and maintain homeostasis. The Long acting oxytetracycline administered at 20and 40 mg/kg body weight mg/kg body weight through intramuscular route in wistar albino rats. Sheep RBC used as antigen. The immunological parameter of Phagocytic Index (PI) was studied in this study. There was no significant (P>0.05) difference in the phagocytic Index in the treated group compared to that of control groups. Ths study was suggestive of long acting acting oxytetracycline formulation having no effect on the cell mediated immnune response in rats.

Keywords: Long acting Oxytetracycline, Phagocytic Index, Immune response.