Abstract

PREPARATION OF NATURAL SUPERDIDINTEGRATES LIKE MUCILAGE OF PLANTAGOOVATA, HIBISCUS ROSA-SINENSISAND TREATED AGAR TO STUDY THEIR EFFECT ON DRUG RELEASE IN COMPARITION TO SYNTHETIC SUPERDISINTEGRANTS BY FORMULATING ATENOLOL ORODISPERSIBLE TABLETS

N. Raghavendra Naveen*, Chakka Gopinath and Buduru Gowthami

Abstract

Atenolol is β1-selective adrenergic blocking agent and widely used in the treatment of hypertension and angina pectoris. Administration of conventional tablets of atenolol has been reported to exhibit fluctuation in the plasma drug levels, resulting either in manifestation of side effects or reduction in drug concentration at the receptor site. Therefore the present investigation was to design a formulation of mouth dissolving tablets of Atenolol by direct compresssion using prepared natural superdisintegrants like Plantago ovata and Treated agar and different natural superdisintegrates like sodium starch glycolate and crospovidone. The blend was examined for angle of repose, bulk density, tapped density, compressibility index and Hausner‟s ratio. The prepared tablets were evaluated for weight variation, hardness, friability, disintegration time, wetting time and dissolution rate. From the present study it can be concluded that natural super disintegrants like Plantago ovate, Hibiscus rosa-sinensis and Treated agar showed better disintegrating and dissolution properties than the most widely used synthetic super disintegrants in the formulation of ODTs. Among all formulations, FP-9 (Plantago ovata of 5%) shows highest drug release of 99.67% within 25mins. It was concluded that superdisintegrants addition technique is a useful method for preparing mouth dissolving tablets by direct compression method.

Keywords: Mouth Dissolving Tablets, Atenolol, Crospovidone, Sodium Starch Glycolate, Plantago Ovata And Treated Agar.