Abstract

EFFECT OF LONG ACTING OXYTETRACYCLINE ON TOTAL LEUCOCYTE COUNT HEMATOLOGICAL PARAMETERS IN WISTAR ALBINO RATS

Ravikumar C.*, Jagadeesh S. Sanganal, Shridhar N.B., Narayanaswamy, H.D., Sunilchandra and U. Shivashankar B.P.

Abstract

The immune system expresses an adaptive response in all the vertebrates against invading microorganisms. The role of immune system is to sustain host defense mechanisms and maintain homeostasis. The Long acting oxytetracycline administered at 20 and 40 mg/kg body weight mg/kg body weight through intramuscular route in wistar albino rats. Sheep RBC used as antigen. The present study was conducted to study the hematological parameters like Total Leucocyte count (TLC) in rats. There was no significant (P>0.05) difference in TLC values in antigen plus long acting oxytetracycline low dose (Group VII) and high dose (Group VIII). There was decrease in the TLC values in treated groups (Group VII and VIII) when compared to antigen (Group V) and antigen plus pyrrolidone (Group VI) group. This is suggestive that long acting oxytetracycline at low and high dose does not affect immnune response in rats.

Keywords: Long acting oxytetracycline, Total Leucocyte Count. Immune response.