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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

POMEGRANATE â€“ A DOUBLE EDGED SWORD FOR THROMBOLYSIS AND OXIDATIVE STRESS

Shalini H. Kumar and Pushpa A.*

Abstract

The well recognized thrombolytic potential of the fruits of Punica granatum in vitro has influenced furthermore to confirm its clot lysing ability in vivo. In the current study, thrombolytic efficiency of the aril and rind of the fruits of pomegranate was analysed in the thrombus induced rat models. The ability of the extract to lyse the preformed clot was confirmed through the haematological profile, antioxidant status and histopathological examination of liver, heart and tail of experimental rats. The extracts of Punica granatum exhibited remarkable thrombolysis.

Keywords: Thrombolysis; Punica granatum; Antioxidant; histopathology

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