Abstract

FORMULATION & EVALUATION OF ANTI INFLAMMATORY CREAM BY USING NSAID’s DRUG WITH HERBAL EXTRACT OF WITHANIA SOMNIFERA FOR THE TREATMENT OF RHEUMATOID ARTHRITIES

*M. Lakshmi Prasanna, Dr. K. Vidyadhar, JSD. Pavan Kumar, P. Mani Kumar, D.L.Anusha, Phalguna Rao and N. Satya Pandu

Abstract

Diclofenac sodium (DS) is a nonsteroidal anti–inflammatory drug[71] (NSAIDs) widely used clinically to reduce inflammation and pain inconditions such as rheumatoid arthritis, menstrual pain, dysmenorrheal, fever, osteoarthritis or acute injury. It has a short halflife in plasma (2 hrs) and only 50% of the drug reaches the circulation. Oral dose of diclofenac potassium causes an increased risk of serious gastrointestinal adverse events including bleeding, ulceration and perforation of the stomach or the intestines which could be fatal.

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