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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

NOVEL MONOCYCLIC ÃŽÂ²-LACTUM MOLECULES: DESIGNED AND CHARACTERIZED AS POSSIBLE ANTIBACTERIAL AGENTS

Vikas A. Desai*, Tejaskumar J. Shah and Bhadreshkumar R. Sudani

Abstract

A reaction of Schiff bases (1a-j) with monochloro acetyl chloride afforded a series of 1-[4â€™-(2â€,4â€-dichloro-5â€-fluoro phenyl)-6â€™-(2â€- thienyl)pyrimidin-2â€™-yl-ureido]-4-substituted phenyl-3-chloro-2- azetidinone derivatives (2a-j) in moderate yields. All the monocyclic Î²-lactam products have been characterized on the basis of physical properties of the molecule and satisfactory spectral (IR, 1H NMR) data. The mechanism of formation of the product is shown. The antibacterial activity of the compounds against some Gram (+) and Gram (-) bacterial strains is reported.

Keywords: Cyclocondensation, Schiff base, Monocyclic ?-lactam, Amide linkage, Antibacterial activity.

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