Abstract

INFLUENCE OF FLUCONAZOLE ON HYPOGLYCAEMIC ACTIVITY OF ORAL ANTIDIABETIC AGENTS IN HEALTHY ALBINO RABBITS

Kadiri Sunil Kumar*, Amrit Patel, Ponnaiah Bharath Rathna Kumar and Ranganatham Venu Priya

Abstract

The influence of fluconazole pretreatment for seven days on the hypoglycaemic effect of rosiglitazone (720 μg/kg, p.o) and pioglitazone (10 mg/kg, p.o) was studied. This study was conducted on healthy albino rabbits of either sex, randomly distributed into 2 different groups. The two groups were pretreated with fluconazole (400 mg/kg, p.o) in 2%w/v gum acacia suspension for seven days. On eighth day rosiglitazone and pioglitazone were administered to respective groups one hour after fluconazole treatment. Blood samples were collected from marginal ear vein at time intervals of 0, 1, 2, 4, 8, 12, 18, and 24 hours and plasma glucose levels were estimated by using GOD/POD method. The study indicated that fluconazole (at therapeutic dose) pretreatment has enhanced the hypoglycaemic effect of rosiglitazone and pioglitazone significantly. Hence it is suggested that during the concomitant usage of fluconazole and thiazolidinediones (rosiglitazone and pioglitazone), the therapeutic drug monitoring is essential and may also require readjusting the dose and frequency of administration of thiazolidinediones (rosiglitazone and pioglitazone).

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