Abstract

SYNTHESIS AND CHARACTERISATION OF SOME THIADIAZOLE DERIVATIVES

V. Niraimathi* and R. Suresh

Abstract

Synthesis of some thiadiazole derivatives were carried out by using dehydrative cyclisation reaction. Compounds were synthesized by reacting ethyl N-pyrrole acetate with thiosemicarbazide in the presence of sulphuric acid/ ammonia to form 2-amino-5-(N-pyrrole methyl) 1,3,4 thiadiazole. The obtained thiadiazole derivatives were reacted with substituted aromatic aldehydes in the presence of acetic acid to form N-substituted 1,3,4 thiadiazole derivatives. All the synthesized compounds were characterized by UV, IR, 1H NMR, and MASS spectroscopy.

Keywords: Pyrrole, 1,3,4-thiadiazole, Schiffs’ base, Microwave synthesis.