Abstract

EMPHASIZING MYOFIBROBLASTS THROUGH ALPHA SMOOTH MUSCLE ACTIN IN ORAL SQUAMOUS CELL CARCINOMA

Afsheen Maqsood, Naseem Ahmed, Tazeen Mustansar, Anwar Ali, Naseer Ahmed, Seema Ashraf*

Abstract

Objective: To highlight the role of Alpha smooth muscle actin by immunohistochemistry in oral squamous cell carcinoma (OSCC). Materials and methods: In this cross-sectional investigation of 80 oral squamous cell carcinoma cases we studied myofibroblasts by means of immunohistochemical evaluation using alpha smooth muscle actin as a biomarker with histological grading constraints. The statistics was exposed to descriptive data and chi-square using SPSS version 16. Results: The study includes 80 patients in which 50 were males (62.5%) and 30 were females (37.5%) age range from 18-78 (mean 45 ± 14.1). A significant association between the extraction of ASMA and histological grading of OSCC has been related with poor prognosis was determined. (P-value: 0.000). Conclusion: This analysis shows that high illustration of alpha smooth muscle actin is valuable for determining an aggressive presentation of oral squamous cell carcinoma.

Keywords: Oral squamous cell carcinoma, Stromal myofibroblasts, Alpha smooth muscle actin.