Abstract

ANTI-AMOEBA ACTIVITY OF MONECHMA CILIATUM (BLACK MAHLAB)

Shayoub Sa. M. El. A*,
Ali. M. Elhassan, Kabbashi A. S., Ahmed. M. El. A., Azza Dawoud H. Dawoud5 and Shayoub M. El. A.

Abstract

Protozoan disease now a days is become more propagation and one of the important cause of deaths specially in developing countries.form long time Herbal plants are source for many drugs used in treatment this protozoan diseases like Emetin, Artemether, quinine. Monechma ciliatum (MC) belongs to the (family: Acanthaceae). M. ciliatum was used in remedy of general body pain, liver, cold, diarrhea and sterility. This study was carried out to evaluate anti-amoebic activity (Entamoeba histolytica) of M. ciliatum extract of different solvent. The extracts of M. ciliatum were screened for it’s anti-malarial activites (Entamoeba histolytica) with different concentrations (500, 250 and 125 ug/ml) and Artemether (the reference control) in vitro. The different solvent of M. ciliatum which exhibited varied from (93.65% to95.96%) mortality with in 72h, at concentration 500 ug/ml; this was compared with metronidazole which gave 92.4% inhibition at the same time and the IC50 was found to be (55.36ug/ml to158.68ug/ml). In conclusion: These studies conducted for M. ciliatum (seeds) was proved to have potent anti-amobic activities against Entamoeba histolytica in vitro.

Keywords: Anti-amoebic activity, Plasmodium falciparum, M. ciliatum, metronidazole, Sudan.