Abstract

ANTI-MALARIAL ACTIVITY OF MONECHMA CILIATUM (BLACK MAHLAB)

Shayoub Sa.M.El.*, Ali. M. Elhassan, Kabbashi A. S., Ahmed. M. El. A.,
Shayoub M. El. A.

Abstract

Malaria is one of the most common major health problems all over the world. Pharmacotherapy is the most common treatment strategy for the disease. Monechma ciliatum (MC) belongs to the (family: Acanthaceae). M. ciliatum was used in remedy of general body pain, liver, cold, diarrhea and sterility. This study was carried out to evaluate anti-malarial activity (Plasmodium falciparum) of M. ciliatum extract of different solvent. The extracts of M. ciliatum were screened for it’s anti-malarial activites (Plasmodium falciparum) with different concentrations (500, 250 and 125 ug/ml) and Artemether (the reference control) in vitro. The different solvent of M. ciliatum which exhibited varied from (70.281% to 83.984%) mortality with in 72h, at concentration 500 ug/ml; this was compared with Artemisinin which gave 85.8% inhibition at the same time and the IC50 was found to be (4.670ug/ml to 65.784). In conclusion: These studies conducted for M. ciliatum (seeds) was proved to have potent anti-malarial activities against Plasmodium falciparum in vitro.

Keywords: Anti-malarial activity, Plasmodium falciparum, M. ciliatum, Artemether, Sudan.