Abstract

SEDATIVE AND ANXIOLYTIC ACTIVITIES OF METHANOL EXTRACT OF LYGODIUM PALMATUM (BERNH.) SW. LEAVES.

Mahmudul Hasan, Mohammad Shah Hafez Kabir*, Md. Abu Aiube Ansary, Md. Rakibul Hasan, Md. Nazmul Huda, Shefatun Nur, Sagar Shil, Akter Hossen, Joy Chakraborty, Abul Hasanat and Md. Rabiul Islam

Abstract

Background: Lygodium palmatum (Bernh.) Sw. leaves are deliberated as worthy traditional medicine. To give a scientific basis for traditional usage of this medicinal plant, the methanol leaf extract (MELP) was used for its sedative and anxiolytic activities. Methods: In this study, the sedative activity was also evaluated using open field test, hole cross test. Besides, elevated plus maze test, hole-board test for exploratory behavior in mice were used to evaluate its anxiolytic activities. The in vivo action was done using mice of both sexes. Result: The extract showed a dose dependent sedative effect. The number of squares traveled by the mice was decreased significantly (P

Keywords: Lygodium palmatum, Sedative, open field, Anxiolytic, EPM.