Abstract

REVIEW ON SOLID LIPID NANOPARTICLES

D. Krishna Veni* and N. Vishal Gupta

Abstract

Solid lipid nanoparticles are the new type of colloidal carrier systems; these are the substitute to the conventional carriers such as liposome’s, micro-particles, nanoparticles and micro- emulsions based on natural macromolecules or synthetic polymers. These consist of an nm range of spherical solid Lipid nanoparticles spherical in shape, which is dispersed in water or an aqueous surfactant solution. Solid Lipid Nanoparticles enhances the oral bioavailability of water insoluble drugs or poorly soluble drugs. This paper gives an outline of advantages and disadvantages, production methods, different types, drug incorporation methods, drug loading capacity and characterization of SLN’s.

Keywords: Colloidal systems, Oral bioavailability, Solid Lipid Nanoparticles, Water Insoluble Drugs.