Abstract

STUDY OF GRWOTH HORMONE AND CORTISOL IN SEVERE ACUTE MALNUTRITION

Pingale Sangeeta Avinash*, Patil Vinayak Wamanrao, Dr. Dhananjay Sangle

Abstract

Development of local therapeutic nutritional intervention for malnourished children is recommended by WHO. Present study was designed to assess the efficacy of the study nutritional intervention in terms of hormone levels before and after the Nutritional Intervention Treatment (NIT) and to find correlation of age with growth hormone in malnourished children. This was Open label prospective parallel group active comparator interventional study,105 Study and 100 control SAM(Severe Acute malnutrition)children of 1 to 5 years of age and either sex were randomly enrolled. Study group was given NIT, providing 2.5 to 3gm Protein and 90-100 kcal/kg body weight/day for three months. Serum growth hormone, cortisol, total protein and albumin levels of both groups were estimated before and after the NIT. Before NIT P value for Growth Hormone and Cortisol were insignificant and after NIT both were significant. Correlation of Growth Hormone with Age was non significant and poor negative at P= 0.057 and pearson correlation coefficient r = -0.186 The investigators conclude that study nutritional intervention is the effective food supplement for the recovery of impaired harmones status in SAM children and growth harmone has nonsificant poor negative correlations with age.

Keywords: Growth hormone, Cortisol, SAM, Correlations.