Abstract

CHRONOPHARMACOTHERAPEUTIC RELEASE OF HMG - COA REDUCTASE INHIBITOR: USING NOVEL COATING TECHNIQUE

M. Swetha*1, B. Rama, V. Sandhiya, Grace Rathnam, U. Ubaidulla, Priyanka Sinha Roy

Abstract

Chronopharmaceutical delivery system of simvastatin was prepared by dip coating method using different concentration of pH sensitive polymers along with hydrophilic diluents (micro crystalline cellulose). The optimized formulation containing 30mg of drug, 100mg of microcrystalline cellulose and different ratio of coating polymer Eudrajit S 100, L 100 and ethylcellulose. The optimized formulation were found to release the drug after a predetermined lag time of 6 hr, at the end of 10 hr it shows 96.2% of drug release. The physicochemical property and post compressed studies were statisfactory. The in-vitro release of core tablet were evaluated by visual method, The in-vitrocomparartive study with marketed products shows statisfactory result at the end of 10th hr. Acid uptake, Rupture test, Swelling test were performed in pH 1.2 and pH 7.4 and there was only negligible percentage of drug release in pH 1.2. SEM and stability were performed and its shows satisfactory result. Compared to conventional dosage form pulsatile drug delivery shows negligible side effects and may release drug according to pathological condition of the disease.

Keywords: MCC, SSG, Dip coated method.