Abstract

EVALUATION OF ANTIULCER ACTIVITY OF AERIAL PART OF ARGEMONE MEXICANA LINN

Raveendra Singh Kushtwar* and Dr. Anurag

Abstract

On the contrary in India, herbal drugs are an integral part of the Indian system of medicine (Ayurveda) which is an ancient and main stream system. The antiulcer activity of aerial part of Argemone mexicana was investigated on ethanol induced model and indomethacin induced model albino wistar rats. In both models the ulcer index was common and it is determined. Ethanolic extract of dose 300 mg/kg and 600mg/kg p.o. produced significant inhibition of gastric lesions induced by ethanol induced and indomethacin induced ulcers. The extract 300mg/kg and 600mg/kg showed significant reduction in gastric acidity and ulcer index as compared to control. Phytochemical analysis showed the presence of glycosides, tannins, alkaloids, saponins and flavonoids. Therefore results of this study indicate the ethanolic extract of aerial part of Argemone mexicana possesses antiulcer activity.

Keywords: Antiulcer activity, Argemone mexicana, Aerial part, Ethanolic extract.