Abstract

INVITRO WASSH OFF COMPARISION STUDIES OF SODIUM ALGINATE MUCOADHESIVE MICROSPHERES USING DIFFERENT POLYMERS

C. Muralikrishna Goud*, M. Sravan, M. Vinod, Dr. H. Ramana, G. Venkateshwarlu

Abstract

The aim of present work is to prolong the gastric residence time of microspheres by formulating into mucoadhesive control release microspheres. The mucoadhesive microspheres were prepared by ionotropic gelation method of polyelectrolyte complexation technique using sodium alginate as control release polymer and carbopol934, hydroxy propyl methyl cellulose, methyl cellulose, tragacanth, sodium carboxy methyl cellulose as mucoadhesive polymers in different proportions and calcium chloride as agent of multivalent cations. The prepared microspheres were characterized by micrometric properties, mean particle size, invitro wash-off test. The data obtained in this study suggests that a micro particulate mucoadhesive dosage forms can be successfully formulated to give prolonged residence time.

Keywords: gastric residence time, sodium alginate, carbopol 934, inotropic gelation method.