Abstract

FORMULATION AND EVALUATION OF NIOSOMAL GEL FOR TRANSDERMAL DELIVERY OF LAMIVUDINE

U.S. Suma, S. Parthiban* and G. P. Senthil Kumar

Abstract

The aim of present study is an attempt to formulate and evaluate niosomal gel for transdermal delivery of Lamivudine for potentially treating HIV and AIDS related condition. Lamivudine is an antiretroviral drug for the treatment of acquired immune deficiency syndrome (AIDS) & Hepatitis. The present study involves the preparation and characterization of Lamivudine entrapped niosomes and finding the drug carrier qualities of the niosomes. The formulation F1-F4 which were prepared by varying the concentration surfactant (span 60) by thin film hydration method. The optimized formulation was incorporated into carbopol gel which is prepared by cold mechanical method and they were characterized for different evaluation parameters such as vesicle size, % entrapment efficiency, drug content, in vitro release and the stability studies was carried out at different temperature. The present study demonstrates the controlled drug release after encapsulation of Lamivudine into niosomal gel.

Keywords: Niosomes, AIDS, Lamivudine, Surfactant, controlled drug delivery.