Abstract

ASSOCIATION OF T45G POLYMORPHISM OF ADIPONECTIN GENE WITH POLYCYSTIC OVARY SYNDROME IN IRAQI WOMEN

Ayat Taha Hameed* and Norrya A. Ali

Abstract

Adiponectin is a 244 – amino acid-long polypeptide, that is exclusively secreted by a dipocytes and acts as a hormone with anti-inflammatory and insulin sensitizing properties, the adiponectin gene contains 3 exons spans 16 kb on chromosome 3q27.45T/G polymorphism in exon 2 of the adiponectin gene which is associated with insulin resistance. The aim of the present study is to study the association of T45G polymorphisms of adiponectin gene with the risk of polycystic ovary syndrome. Fifty patients and Twenty five controls were enrolled in this study. Significance difference was found between genetic variation of adiponectin gene T45G SNP and the increased risk of PCOS in women Iraqi population. The distribution of T45G polymorphisms of adiponectin gene in PCOS patients was higher than in controls.

Keywords: Adiponectin, Polycystic ovary syndrome, 45T/G polymorphism.