Abstract

DESIGN AND CHARACTERIZATION OF CONTROLLED RELEASE MICROCAPSULES OF ACARBOSE USING CELLULOSE POLYMERS

Dr. Abdul Hasan Sathali. A.* and Rajesh Kanna G.

Abstract

Controlled release microcapsules of acarbose were prepared by Coacervation phase separation technique using cellulose polymers (Ethyl cellulose, Hydroxy Propyl Methyl Cellulose k-15, Hydroxy Propyl Methyl Cellulose k-100 and Sodium Carboxy Methyl Cellulose). Microencapsulation of acarbose was done to achieve controlled drug release profile suitable for per oral administration. The Fourier Transform-Infra Red spectrum(FT-IR) and Differential Scanning Colorimetry(DSC) thermogram of pure drug and drugpolymer blend showed the stable character of Acarbose in the microcapsules. The prepared microcapsules were evaluated for different quality control parameter like; size analysis, drug content, encapsulation efficiency and drug release characteristics etc. Results of study revealed that Acarbose release from microcapsules greatly affected by different polymers with different core: coat ratio. A precise UV-Visible method also developed for the estimation of Acarbose in prepared dosage form. Microcapsules showing spherical surface, which was confirmed by scanning electron microscopy study. In-vitro dissolution studies indicated that drug release from microcapsules followed zero order kinetics; the release could be extended up to 12 hours, and non-fickian diffusion was involved.

Keywords: Controlled release microcapsules, Acarbose, Cellulose polymers, Coacervation phase separation.