Abstract

PROTECTIVE EFFECTS OF FISH OIL (OMEGA-3 FATTY ACIDS) AGAINST EXPERIMENTALLY (1-METHYL -4- PHENYL – 1, 2, 3, 6 TETRAHYDROPYRIDINE HYDROCHLORIDE) INDUCED PARKINSON’S DISEASE IN MICE

*Elandevan.C.K, Sylvia Santhakumari.A, Nirmala.P

Abstract

Parkinson’s disease (PD) is a common neurological disorder due to degeneration of substantia nigra pars compacta (SNpc). The aim of the present study was to evaluate the neuroprotective action of fish oil containing omega-3 fatty acids against experimentally induced Parkinson’s disease. Biochemical analysis MPTP treated mice showed a dramatic increase in lipid peroxidation, anti-oxidant enzymes and histopathology showed severe damage to the neuronal cells of SNpc and corpus striatum. Pretreatment with fish oil treated mice showed significant reduction in lipid peroxidation, antioxidants which could be due to an adaptive response to overcome the enhanced oxidative stress and attenuated significantly. The histopathology fish oil treated mice showed less damage and less microglial activation. Pretreatment with fish oil attenuated significantly the MPTP-induced activation of microglia in SNpc and corpus striatum.

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