Abstract

ASPECTS OF SOLUBILISATION: A REVIEW

*Amrit Kaur, Dr. D. N. Prasad, Dr. J. S. Dua, Muse Menra and Neha Sharma

Abstract

Many water soluble drugs are present in the BCS class П category, which are characterized by low solubility and high permeability. By increasing the dissolution rate, the solubility of drug can be easily enhanced. Various solubility enhancement techniques are available for increasing the solubility as well as permeability of drugs like micronization, complexation, cosolvent addition, conservation and soli dispersion. As oral route is one of the most desirable and preffered method for drug administration, thus solubility of drug is a major challenge in formulation designing. About 40% of the orally administered drugs are having solubility problems. Thus, because of these solubility problems, the bioavailability of drugs also gets affected. This makes the solubility enhancement of drugs necessary. In this review we concentrate on the solubility and various problems related to the solubility and various techniques which can be used to enhance the solubility.

Keywords: Solubility, Bioavailability, Dissolution.