Abstract

ANTI-CANCER EFFECT OF NANO PALLADIUM-LIPOIC ACID COMPLEX FORMULATION AGAINST LUNG CANCER CELL LINE

Kanchana M*, Savitha D & Jeevitha D

Abstract

The ever-increasing use of plant-derived phytochemicals and thiol rich molecules for the synthesis and stabilization of non-toxic metallic nanoparticles has gained increasing momentum for anti-cancer drug design and bioavailability. In this work, we synthesised a nanoformulation using Solanum trilobatum (SN) phytochemicals and dihydrolipoic acid (LA) for the production of palladium nanoparticles (PDNPs). The synthesized nanoparticles were analyzed by TEM. Further, this study evaluates the therapeutic efficacy of SNPDNPs and SNPD-LANPs in human lung (A549) cancer cells including cell viability comparison, cell morphology analysis and oxidative stress parameters. Accordingly, SNPD-LANPs exhibited significant cytotoxicity in A549 cells in a dose-dependent manner compared to SNPDNPs as determined by MTT and LDH analysis. SNPD-LANPs and SNPDNPs treatment also revealed significant (P

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