Abstract

RENAL PROTECTIVE ACTIVITY OF HELIOTROPIUM INDICUM IN RIFAMPICIN INDUCED NEPHROTOXICITY RATS

Mokhalad Waheeb Abdullah, Jaffar S. K., Ghousia Begum and Balasubramanian Sathyamurthy*

Abstract

The nephro protective effect of whole plant of ethanolic extract of Heliotropium indicum was confirmed by our study. In the present study, the whole plant of ethanolic extract of Heliotropium indicum significantly reduced the toxicant elevated levels. It was observed the extract of Heliotropium indicum treated group animals were found to reduce such changes in kidney histology induced by Rifampicin, indicating nephroprotection. Heliotropium indicum contain phenols, flavonoids, triterpenoids, alkaloids and saponins offers organ protection by virtue of their free radical scavenging activity. Phyto constituent analysis showed the presence of phenols, flavonoids, triterpenoids, alkaloids and saponins as phytoconstituents. Based on improvement in serum and urine marker levels, histopathological studies, antioxidant enzymes and presence of phytoconstituents the ethnolic extract of Heliotropium indicum possesses nephroprotective activity.

Keywords: Rifampicin, nephrotoxicity, Heliotropium indicum, ethanolic extract, soxhlet apparatus.